Endocrine Abstracts

Background: Patients with CHH and KS share eunuchoid body proportions of skeleton compared to normal male subjects. On the contrary, testosterone levels at puberty are lower in CHH patients compared to KS patients.Aim: To compare anthropometric measurements of adult male CHH vs KS patients.Methods: A prospective, cross-sectional, observational study was conducted. CHH patients were subdivided into 2 subgroups according to the timin...

Introduction: Thyroid FNAB is the gold standard to discriminate malignant from benign thyroid nodules. However, inadequate cytology ranges from 1 to 20% (up to 33.6%) in different settings and could depend on several factors, including the operator’s skills.Aim: To evaluate the effect of operator’s experience on US-FNAB diagnostic adequacy we reviewed 7029 US-FNABs performed from January 2006 to March 2009.Materials and M...

Introduction: There is no consensus about the usefulness of repeating the US-FNAB during the follow-up of nodules when a benign (Thy2) or indeterminate (Thy3) report is obtained at first US-FNAB.Aim of the study: To investigate the clinical value of repeating US-FNAB after a previous adequate Thy2 or Thy3 US-FNAB.Methods: We reviewed the US-FNABs performed from 2006 to 2009. All clinical data of the patients were collected and anal...

Introduction: At puberty, the raise of serum estradiol (E2) (after testosterone conversion) is needed to fuse ephiphyses and to complete bone maturation in boys. Owing to severe hypogonadism and very low circulating testosterone, adult men with congenital hypogonadotropic hypogonadism (CHH) may present with unfused epiphyses and continuing linear growth if androgen deficiency is unrecognized and untreated. In order to establish the minimal amount of sex steroids nee...

Introduction: US-FNAB is the most cost/effective and accurate diagnostic procedure for the evaluation of thyroid nodules. In the clinic, the nursing assistance is not always available for the US-FNAB procedure in all endocrinological centers and its value remains to be established.Aim of the Study: To demonstrate the role of nursing assistance in US-FNAB procedures in improving the efficiency of this procedure.Methods: All clinical...

Introduction: Male hypogonadism is very frequent in men treated with highly active anti-retroviral therapy (HAART) for Human Immunodeficiency Virus-1 (HIV-1) infection, reaching a prevalence of about 20%. Literature data regarding the time course of serum total testosterone (T) levels in these patients are lacking.Aim of the study: To evaluate changes of T levels over time in HIV-positive men with an initial finding of low T (<300 ng/dl).<p class...

Introduction: Several data suggest that male hypogonadism occurs frequently in men with type 2 diabetes mellitus (T2DM) but underlying pathophysiological mechanism remains partially unknown. In order to investigate the short term effect of hyperglycaemic state on hypothalamic–pituitary–gonadal axis we prospectively studied 18 men with T2DM younger than 55 years at the time of first diagnosis of T2DM. We compared men with HbA1c≥9.0% with men with HbA1c≤9.0...

Introduction: Familial adenomatous polyposis (FAP) is a dominantly inherited disease characterized by colorectal adenomas, extracolonic gastrointestinal manifestations and extraintestinal diseases. Among them, differentiated thyroid cancer (DTC) is considered very frequent with an approximately risk 160 times higher than in general population, and with a prevalence of the cribriform-morular variant. As this esteem comes from scattered data, we evaluated in a prospective contro...